Overview | Cell Structures | Cell Migration | Cell Division |
Mechanism of Stiffness Sensing Revealed with a Composite Substrate |
Wong et al., Proc. Natl. Acad. Sci. USA 111:17176-17181 (2014) |
Our previous experiment using composite substrate, where an array of small photoresist islands are grafted on the surface of soft polyacrylamide gels, suggests that cellular stiffness sensing occurs across a distance of tens of microns rather than within single focal adhesions . To further understand the mechanism, we simulate stiff-soft transition by placing a large, stiff island next to a matrix of small islands separated by either soft or stiff gels. After the initial adhesion to the large island, subsequent responses of the cell may depend on how cells probe and respond to the adjacent small islands. |